SFPQ Promotes Homologous Recombination via mRNA Stabilization of RAD51 and Its Paralogs
Sofia Gotthold, Keile R. Hansen, Andrew N. Brown, Soham P. Chowdhury, Christine M. Joyce, Viraj Vinish, Sofie I. Rodriguez, Sambhav Jain, Hannah I. Ghasemi, Amanda C. Yoon, Julien Bacal, Meghan A. Morrissey, Brooke M. Gardner, Chris D. Richardson
This study identifies SFPQ as a factor promoting homologous recombination by stabilizing RAD51 and its paralogs' mRNA, independent of DSB localization or p53 activation.
Journal of Molecular Biology · Feb 10, 2026Peer-reviewedMolecular Biology