iPSC-derived NF1-CDKN2A-PRC2 deficient neural crest mimics MPNST glial-to-neuro-mesenchymal transition and uncover new therapeutic opportunities
Itziar Uriarte-Arrazola, Miriam Magallón‐Lorenz, Juana Fernández‐Rodríguez, Jiajing Zhang, Emily Lee, Sara Ortega‐Bertran, Edgar Creus‐Bachiller, Judit Farrés-Casas, Kelli M. Wilson, Crystal McKnight, Katlin Recabo, Ignacio Blanco, Héctor Salvador, Cleofé Romagosa, Conxi Lázaro, , Eduard Serra
This paper uses iPSC-derived neural crest models to mimic MPNST progression and identifies PARPi as a potential therapy for PRC2-deficient tumors.
bioRxiv · Aug 13, 2025 · PreprintCancer Biology