Increased Neurite Orientation-Dispersion and Density in the TgCRND8 Mouse Model of Amyloidosis: Inverse Relation with Functional Connectome Clustering and Modulation by Interleukin-6
Luis M. Colón-Pérez, Kristen R. Ibanez, Mallory Suarez, Kristin Torroella, Kelly Acuna, Edward Ofori, Yona Levites, David E. Vaillancourt, Todd Eliot Golde, Paramita Chakrabarty, Marcelo Febo
The paper uses dMRI to study how Aβ and IL6 affect microstructure in TgCRND8 mice, finding increased neurite density and dispersion linked to reduced functional network organization.
bioRxiv · Feb 27, 2019 · PreprintNeuroscience