Paramita Chakrabarty

This study shows that PERK deficiency worsens molecular, structural, and network damage in mice after repetitive mild traumatic brain injury.

This paper examines how beta-amyloid affects static and dynamic functional connectomes in mice and humans, finding species-specific differences in network stability and dynamics.

This study examines age and sex effects on MDSCs in sepsis using single-cell RNA sequencing, finding differences in expansion, transcriptome, and metabolism.

The paper examines how amyloidosis affects functional network hub topology and gene expression in male and female APP-PS1 mice, finding sex-dependent changes in connectivity and gene signatures.

This study examines how acetylation and phosphorylation mutations affect tau aggregation and seeding in Alzheimer's and PSP models.

This study identifies a PERK-B/DLX1 pathway as a novel driver of tau pathology in human PSP and flies, showing DLX1 promotes tau toxicity.

This study identifies plasma proteomic signatures associated with repetitive head impact exposure and CTE, linking them to immune, mitochondrial, and metabolic pathways and cognitive decline.

This study maps epigenetic changes in MDSCs after sepsis, revealing age- and sex-specific chromatin remodeling linked to immune dysfunction.

This study examines how APOE4 and APOE3 homozygosity affect functional brain networks and contextual memory in mice across age, showing differential network development and memory disruption in APOE4 adults.

This study shows human APOE variants reduce both diffuse and fibrillar Aβ deposits in transgenic mouse models compared to mouse Apoe, with APOE3 more effective than APOE4 in some contexts.

This study shows that deletion of Abi3/Gngt2 affects amyloid β and tau pathologies differently with age in AD models.

The paper compares microglial transcriptomic responses to Aβ peptide aggregates ex vivo and in vivo, finding distinct responses and highlighting the limitations of using ex vivo models to predict in vivo behavior.

The paper uses dMRI to study how Aβ and IL6 affect microstructure in TgCRND8 mice, finding increased neurite density and dispersion linked to reduced functional network organization.

The paper confirms that the PLCG2 P522R variant is protective against Alzheimer’s disease and shows it weakly activates PLCG2 enzyme function in microglia.

The paper identifies gene expression signatures in human and mouse brains linked to Alzheimer's disease and finds species-specific and shared patterns across neurodegenerative models.