Intercalated amygdala dysfunction drives extinction deficits in the Sapap3 mouse model of obsessive-compulsive disorder
Robyn St. Laurent, Kelly M. Kusche, Anatol C. Kreitzer, Robert C. Malenka
This study shows that dysfunction in the dorsal intercalated nuclei of the amygdala (ITCd) in Sapap3-null mice leads to impaired extinction of avoidant behavior, which can be rescued by optogenetic inhibition of ITCd.
bioRxiv · Feb 12, 2024 · PreprintNeuroscience