Nf2 fine-tunes proliferation and tissue alignment during closure of the optic fissure in the embryonic mouse eye
Wesley Sun, Sara Ramirez, Kelly Spiller, Yan Zhao, Sabine Fuhrmann
This study identifies Nf2's role in regulating proliferation and tissue alignment during optic fissure closure in the mouse eye, showing that its loss causes coloboma due to RPE hyperproliferation and cytoskeletal disorganization.
Human Molecular Genetics · Oct 13, 2020Peer-reviewedDevelopmental Biology