Sabine Fuhrmann

Direct comparison of constitutive Rax-Cre transgenic drivers that activate in the mouse embryonic eye field

The paper compares two Rax-Cre transgenic drivers in mice to evaluate their Cre activity in the embryonic eye and extra-ocular tissues.

Diet gel-based oral drug delivery system for controlled dosing of small molecules for microglia depletion and inducible Cre recombination in mice

This study develops a diet gel-based oral drug delivery system for controlled dosing of PLX5622 and Tamoxifen in mice, achieving high microglia depletion and inducible Cre recombination.

Dicer loss in Muller glia leads to a defined sequence of pathological events beginning with cone dysfunction

This study investigates the sequence of pathological events caused by Dicer loss in Muller glia, showing cone dysfunction precedes rod degeneration and retinal remodeling.

Loss of Cdc42 causes abnormal optic cup morphogenesis and microphthalmia in mouse

This study shows that loss of Cdc42 in mice causes defects in optic cup morphogenesis, leading to microphthalmia and coloboma due to impaired cell polarity, junctions, and proliferation.

Loss of Tbx3 in mouse eye causes retinal angiogenesis defects reminiscent of human disease

This study shows that Tbx3 loss in mice causes retinal angiogenesis defects similar to human ROP and FEVR, highlighting its role in eye development.

Porcn is essential for growth and invagination of the mammalian optic cup

This study shows that Porcn is essential for optic vesicle growth and morphogenesis in mammals by regulating proliferation and survival, and its loss leads to microphthalmia in FDH patients.

Nf2 fine-tunes proliferation and tissue alignment during closure of the optic fissure in the embryonic mouse eye

This study identifies Nf2's role in regulating proliferation and tissue alignment during optic fissure closure in the mouse eye, showing that its loss causes coloboma due to RPE hyperproliferation and cytoskeletal disorganization.