Reciprocal regulation of the H3 histamine receptor in Rett syndrome and MECP2 Duplication syndrome: implications for therapeutic development
Kelly Weiss, Sheryl Anne D. Vermudez, Geanne A. Freitas, Shalini Dogra, Mac J. Meadows, Rocco G. Gogliotti, Colleen Marie Niswender
The paper investigates the reciprocal regulation of the H3 histamine receptor in Rett syndrome and MECP2 Duplication syndrome, showing reduced H3 receptor expression in RTT and increased in MDS, and evaluates potential therapeutic effects of agonist and inverse agonist drugs.
bioRxiv · Oct 30, 2025 · PreprintNeuroscience