Shalini Dogra

This study investigates the role of H3R in DRG neurons and shows that an H3R inverse agonist reduces mechanical hypersensitivity in neuropathic pain without affecting thermal pain.

The paper investigates the reciprocal regulation of the H3 histamine receptor in Rett syndrome and MECP2 Duplication syndrome, showing reduced H3 receptor expression in RTT and increased in MDS, and evaluates potential therapeutic effects of agonist and inverse agonist drugs.

This study shows that KOR activation reduces BDNF expression in the PFC via HDAC5-mediated epigenetic silencing, contributing to depression-like symptoms in mice.