Colleen Marie Niswender

This study shows CVN636 enhances orthosteric agonist responses at mGlu7 homodimers but not heterodimers.

The paper shows that signaling in mGlu1/5 heterodimers is dominated by the mGlu protomer, leading to emergent signaling and allosteric inversion, with implications for drug design.

The paper investigates mGlu7 expression in Rett syndrome and shows that mGlu7 PAMs can reduce apneas in RTT patients.

The paper investigates the reciprocal regulation of the H3 histamine receptor in Rett syndrome and MECP2 Duplication syndrome, showing reduced H3 receptor expression in RTT and increased in MDS, and evaluates potential therapeutic effects of agonist and inverse agonist drugs.

The paper shows that phospholipase D is essential for M1 PAM-induced long-term depression in rodent prefrontal cortex, and biased M1 PAMs that do not activate PLD have distinct effects on cortical plasticity.