Surface Complex V couples proton gradient across the plasma membrane to ATP production in cancer
Daniel Pelaez, Samantha A. McLaughlin, Kendall Knechtel, Zelia Correa, J. William Harbour
The paper shows cancer cells use a proton gradient from lactate export to drive ATP production via plasma membrane-localized ATP synthases, resolving the Warburg effect's energetic inefficiency.
bioRxiv · May 21, 2026 · PreprintCancer Biology