Contrasting regional architectures of schizophrenia and other complex diseases using fast variance components analysis
Po-Ru Loh, Gaurav Bhatia, Alexander Gusev, Hilary K Finucane, Brendan K Bulik-Sullivan, Samuela J Pollack, Schizophrenia Working Group of the Psychiatric Genomics Consortiumy, Teresa R de Candia, Sang Hong Lee, Naomi R Wray, Kenneth S Kendler, Michael C O’Donovan, Benjamin M Neale, Nick Patterson, Alkes L Price
The paper analyzes the genetic architecture of schizophrenia and nine complex diseases using a fast variance components analysis, finding polygenic patterns and significant genetic correlations.
bioRxiv · Jun 5, 2015 · PreprintGenetics