Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types
Hilary K. Finucane, Yakir Reshef, Verneri Anttila, Kamil Slowikowski, Alexander Gusev, Andrea Byrnes, Steven Gazal, Po‐Ru Loh, Caleb A. Lareau, Noam Shoresh F, Giulio Genovese, Arpiar B. Saunders, Evan Z. Macosko, Samuela J Pollack, John R. B. Perry, , Alkes L. Price
The paper uses gene expression data and GWAS summary statistics to identify disease-relevant tissues and cell types by detecting heritability enrichments in gene-specific expression regions.
Nature Genetics · Apr 1, 2018Peer-reviewedGenetics