Development of a novel VHH intrabody targeting the N17 region of huntingtin exon 1 protein that prevents inclusion body formation.
Florence D.M. Wavreil, Wouter Pos, Menno Spits, Alicia Sanz Sanz, Kes Rietveld, Roos van Dam, Martino Böhne, Sander J. H. van Deventer, Sabine Schipper-Krom, Eric A. Reits
This paper develops a VHH intrabody that targets the N17 region of mHTT exon 1, reducing insoluble mHTT species and preventing inclusion body formation.
bioRxiv · Apr 13, 2026 · PreprintNeuroscience