Cyclic-Phe-Pro Binds the ToxRS Interface to Promote Signal Transduction in Vibrio vulnificus
Tae-Yeon Kim, Woo‐Chan Ahn, Jeong‐a Kim, Keun-Woo Lee, Soyee Kim, Kwang‐Hyun Park, Eui‐Jeon Woo, Kun‐Soo Kim
This study identifies how cFP binds ToxRS in V. vulnificus to activate virulence genes by stabilizing the ToxR-ToxS heterodimer and enhancing promoter binding.
bioRxiv · Jul 22, 2026 · PreprintBiochemistry