Author

Kevin Fleisher

California Institute of Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Approach:graph neural network· 2 Assay:spatial transcriptomics· 2 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Rex LiuiD· 2 shared Yuning You· 2 shared James GornetiD· 1 shared Jiayi YiniD· 1 shared Lydia Chen· 1 shared Matt Thomson· 1 shared Matt W. ThomsoniD· 1 shared Willis Zhang· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersBioinformatics

Rex LiuORCID

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2 papers

Recent·Most cited

A Generative Virtual Tissue Model Enables Computational Design of Therapeutic Perturbation Strategies

Yunrui Lu, Willis Zhang, Yu-Jen Chen, Jiayi Yin, Lydia Chen, Kevin Fleisher, James Gornet, Rex Liu, Zitong Jerry Wang, Yan Poon, Yuning You, Matt W. Thomson

This paper introduces CIFM, a generative virtual tissue model that simulates transcriptional dynamics under therapeutic conditions to design immunotherapy strategies for cancer and autoimmune diseases.

bioRxiv · Aug 20, 2026 · PreprintBioinformatics

Building Foundation Models to Characterize Cellular Interactions via Geometric Self-Supervised Learning on Spatial Genomics

Yuning You, Zitong Jerry Wang, Kevin Fleisher, Rex Liu, Matt Thomson

This paper introduces CI-FM, a foundation model for analyzing cellular interactions in spatial genomics using geometric graph neural networks, achieving high correlation and low error in gene expression inference.

bioRxiv · Jan 25, 2025 · PreprintBioinformatics