Author

Kevin Gao

New York University

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Biochemistry· 1

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Approach:experimental assay· 1 Organism:human· 1

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Jérôme PerrardiD· 1 shared Katherine Ring· 1 shared Susan Harless SmithiD· 1 shared

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1 shared paperBiochemistry

Jérôme PerrardORCID

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1 paper

Recent·Most cited

Deltex and RING-UIM E3 ligases cooperate to create a ubiquitin-ADP-ribose hybrid mark on tankyrase, promoting its stabilization

Jérôme Perrard, Kevin Gao, Katherine Ring, Susan Harless Smith

The paper identifies a mechanism where Deltex E3 ligases modify tankyrase with a ubiquitin-MAR hybrid mark, preventing PAR formation and stabilizing tankyrase through interaction with RNF114 and RNF166.

Science Advances · Sep 3, 2025Peer-reviewedBiochemistry