Author

Jérôme Perrard

University of LausanneORCID 0000-0003-4506-8108Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Assay:CUT&Tag· 1 Research Focus:differential expression· 1 Approach:statistical model· 1

Frequent Co-Authors

Claudiane GuayiD· 3 shared Romano RegazziiD· 3 shared Cristina CosentinoiD· 2 shared Cécile JacovettiiD· 1 shared Cristina Aguayo‐MazzucatoiD· 1 shared Daniela FignaniiD· 1 shared Elena AielloiD· 1 shared Eleonora ManganoiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersMolecular Biology

Claudiane GuayORCID

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4 papers

Recent·Most cited

Molecular BiologyScientific ReportsPeer-reviewedMar 17, 2026

The MIME-seq technique allows to monitor the interaction of small non-coding RNAs with Argonaute proteins and their transfer to other cells

Jérôme Perrard, Claudiane Guay, Nadège Zanou, Romano Regazzi

The MIME-seq technique protects small non-coding RNAs from oxidation to enable detection of their interaction with Argonaute proteins and transfer between cells.

DOI 10.1038/s41598-026-44270-5

humanCUT&Tag

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Molecular BiologyRNA BiologyPeer-reviewedMar 13, 2026

Role of small intronic RNAs in the crosstalk between immune cells and beta-cells during type 1 diabetes development

Shagun Poddar, Flora Brozzi, Cristina Cosentino…·Romano Regazzi

The paper identifies two small intronic RNAs, sinR-D and sinR-T, that are transferred between immune cells and beta-cells in type 1 diabetes, with sinR-D promoting beta-cell apoptosis.

1 citation

mouseexperimental assay

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Molecular BiologybioRxivPreprintDec 18, 2025

Small non-coding RNA profiling reveals inflammatory and mitochondrial related changes in aging β-cells and islet macrophages

Claudiane Guay, Jérôme Perrard, Eleonora Mangano…·Romano Regazzi

This study profiles small non-coding RNAs in aging β-cells and islet macrophages, identifying age-related changes in miRNAs and tRFs linked to inflammation and mitochondrial function.

DOI 10.64898/2025.12.17.694889

mousestatistical model

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BiochemistryScience AdvancesPeer-reviewedSep 3, 2025

Deltex and RING-UIM E3 ligases cooperate to create a ubiquitin-ADP-ribose hybrid mark on tankyrase, promoting its stabilization

Jérôme Perrard, Kevin Gao, Katherine Ring, Susan Harless Smith

The paper identifies a mechanism where Deltex E3 ligases modify tankyrase with a ubiquitin-MAR hybrid mark, preventing PAR formation and stabilizing tankyrase through interaction with RNF114 and RNF166.

20 citationstop 2%

humanexperimental assay

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