Adoptive Transfer of CD49a+ Tissue Resident memory cells reverses pulmonary fibrosis in mice.
Samuel L Collins, Yee Chan-Li, Kevin Shenderov, Astrid Gillich, Andrew M. Nelson, Jeffrey M. Loube, Wayne A Mitzner, Jonathan D. Powell, Maureen R. Horton
This paper demonstrates that adoptive transfer of CD49a+ CD4+ tissue resident memory T cells reverses established pulmonary fibrosis in mice by reducing collagen and improving lung function.
bioRxiv · Mar 13, 2024 · PreprintImmunology