Kevin Vo

Aging alters mRNA processing in the mouse ovary

This study identifies age-related changes in transcript variants in mouse ovaries, revealing that differential expression of alternative transcripts is often overlooked by traditional gene expression analyses.

Importance of transcript variants in transcriptome analyses

The paper shows that ignoring transcript variants in RNA-Seq analysis leads to inaccurate conclusions about gene expression, as over 80% of transcript expression changes are missed when using gene-level data alone.

Epigenetic and transcriptional regulation of ovarian development altered in ErβKO ovaries

This study identifies dysregulated epigenetic regulators and transcription factors in ErβKO rat ovaries during postnatal development, leading to altered follicle activation and downstream gene expression.