Patrick E. Fields

The paper identifies mRNA isoform switching as critical for mural and cumulus granulosa cell differentiation in mice by analyzing transcriptomes and differential transcript isoform expression.

This study identifies age-related changes in transcript variants in mouse ovaries, revealing that differential expression of alternative transcripts is often overlooked by traditional gene expression analyses.

The paper shows that ignoring transcript variants in RNA-Seq analysis leads to inaccurate conclusions about gene expression, as over 80% of transcript expression changes are missed when using gene-level data alone.

This study identifies dysregulated epigenetic regulators and transcription factors in ErβKO rat ovaries during postnatal development, leading to altered follicle activation and downstream gene expression.

This study shows that DOT1L regulates TRPC6 expression in erythroid progenitor cells, affecting calcium influx and erythropoiesis.

This study shows that Dot1L-dependent H3K79 methylation is essential for efficient HDR of DNA double strand breaks and genomic stability.

This study investigates the role of DOT1L in hematopoietic progenitor cells by analyzing transcriptomes of knockout and mutant models, revealing its function as a transcriptional repressor.

This study shows that DOT1L methyltransferase activity is essential for early murine hematopoiesis, as its loss causes embryonic lethality and genomic instability in hematopoietic progenitors.