Anti-tumor effects of a novel cell penetrating peptide-based therapeutic approach to target Lactate Dehydrogenase C (LDHC) in triple negative breast cancer.
Hanan Qasem, Adviti Naik, Tricia Gomez, Janarthanan Ponraj, Umar Jafar, Martin Sikhondze, Remy Thomas, Khaled A Mahmoud, Julie V. Decock
This paper evaluates four cell-penetrating peptides for delivering LDHC siRNA to TNBC cells, finding that two show effective LDHC knockdown and tumor reduction in zebrafish models.
bioRxiv · Mar 11, 2025 · PreprintCancer Biology