Janarthanan Ponraj

This paper evaluates four cell-penetrating peptides for delivering LDHC siRNA to TNBC cells, finding that two show effective LDHC knockdown and tumor reduction in zebrafish models.

This study examines alpha-synuclein pathology in metachromatic leukodystrophy (MLD) brain tissue, finding seed-competent alpha-synuclein conformers in juvenile-onset cases, similar to Lewy body diseases.

The paper shows that MARCKS masks PIP2, arresting SNARE assembly and vesicle fusion, while PIP2 unmasking by Ca2+/CaM or PKC-epsilon rescues fusion and enhances synaptotagmin-1 activity.

This study shows cholesterol is required for Ca2+-dependent vesicle fusion by stabilizing synaptotagmin-1-induced membrane bending.