BiophysicseLifePeer-reviewed
The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A
Cristina Olivieri, Yingjie Wang, Caitlin Walker…·Gianluigi Veglia
This study identifies the αC-β4 loop as a key regulator of allosteric cooperativity between nucleotide and substrate in PKA-C through simulations and mutagenesis experiments.