Combinatorial adapter targeting enables AND-gate activation of AdCAR T cells in pancreatic cancer but reveals donor-dependent activation thresholds
Camille Dourlens, Kim Vanderliek, Olaf Hardt, Daniel Schaefer
This study shows that combinatorial adapter targeting in AdCAR T cells can selectively kill pancreatic cancer cells while avoiding off-tumor toxicity, but activation thresholds vary between donors.
bioRxiv · Jul 9, 2026 · PreprintImmunology