Negative affective states are not detected in rats following an intravenous self-administration regimen leading to incubation of oxycodone craving
Amanda M. Wunsch, Kimberley A Mount, Asia R. Guzman, Alex B. Kawa, Jonathan G Westlake, Hayley M Kuhn, Madelyn M Beutler, Marina E. Wolf
This study investigates whether negative affective states persist in rats after oxycodone self-administration and abstinence, finding no significant differences in negative affect tests compared to saline controls.
bioRxiv · Apr 8, 2026 · PreprintNeuroscience