Inferring disruption of directed graphs using LIKA reveals altered protein phosphorylation networks in schizophrenia
Lujing Zhang, Andrew G. DeMarco, Kimia Ghafari, Bernie Devlin, Matthew L. MacDonald, Kathryn Roeder
LIKA, a likelihood model over many-to-many kinase-substrate networks, beats KSEA in simulations with shared substrates, recovers EGFR and ABL1 in cell lines, and ranks MAPK3 first in schizophrenia cortex.
bioRxiv · Aug 7, 2026 · PreprintBioinformatics✦ In-depth digest