Matthew L. MacDonald

Autism genes converge on three functional programs organized by neuronal subclass, developmental timing, and cortical patterning

This study identifies three functional programs impacted by autism genes, contextualized across neuronal subclasses, developmental timing, and cortical regions.

Proteomic profiling across early postnatal development of midbrain dopamine axons innervating the dorsal striatum

The paper maps the proteomic changes in midbrain dopamine axons during postnatal development, identifying temporal dynamics of protein expression and linking them to disease risk.

Estimating protein isoform abundances with PAQu

PAQu estimates protein isoform abundances using multiomic data, outperforming existing methods and revealing increased C4A isoform levels in schizophrenia.

Inferring disruption of directed graphs using LIKA reveals altered protein phosphorylation networks in schizophrenia

LIKA, a likelihood model over many-to-many kinase-substrate networks, beats KSEA in simulations with shared substrates, recovers EGFR and ABL1 in cell lines, and ranks MAPK3 first in schizophrenia cortex.

PACS1 syndrome variant alters proteomic landscape of developing cortical organoids

This study examines how the PACS1 p.R203W variant affects the proteomic landscape of brain organoids, identifying dysregulated proteins and processes linked to neurodevelopmental disorders.

Circadian rhythm disruptions associated with opioid use disorder in the synaptic proteomes of the human dorsolateral prefrontal cortex and nucleus accumbens

The paper identifies synaptic protein alterations and circadian rhythm disruptions in brain regions associated with opioid use disorder using proteomics.

Dynamic proteomic and phosphoproteomic atlas of corticostriatal axon neurodevelopment

The paper maps the cell-type specific proteome and phosphoproteome of corticostriatal axons across postnatal development, identifying proline-directed kinases as key developmental regulators.

CACNB4 overexpression decreases dendritic spine density in sex-specific manner

This study shows that overexpressing CACNB4 reduces small dendritic spine density in female mice but not males, linked to sex differences in the {beta}4 interactome.

Cell type and subcellular compartment specific APEX2 proximity labeling proteomics in the mouse brain

The paper develops a method to profile cell-type specific subcellular proteomes in the mouse brain using APEX2 proximity labeling.

Postsynaptic serine racemase regulates NMDA receptor function

This study shows that postsynaptic serine racemase regulates NMDA receptor function in mouse hippocampal neurons, with age-dependent effects on long-term potentiation and GluN2B expression.

Synaptic Proteome Alterations in the Primary Auditory Cortex of Schizophrenia

This study identifies synaptic proteome alterations in the primary auditory cortex of schizophrenia patients, showing coordinated changes in postsynaptic proteins not explained by global protein levels or confounding factors.