Utility of Cellular Measurements of Non-Specific Endocytosis to Assess the Target-Independent Clearance of Monoclonal Antibodies
Mark A. Bryniarski, Md Tariqul Haque Tuhin, Carolyn D. Shomin, Fatemeh Nasrollahi, Eunkyung Clare Ko, Marcus Soto, Kyu Chung, Carrie Poon-Andersen, Ronya Primack, Diana Wong, Esperanza Ojeda, John Chung, Kevin D. Cook, Kip P. Conner
The paper develops a cell-based assay to measure non-specific endocytosis of monoclonal antibodies and shows that high non-specific uptake correlates with target-independent clearance and low bioavailability.
bioRxiv · Apr 16, 2024Biochemistry