BiochemistryJournal of Pharmaceutical SciencesPeer-reviewed
Utility of Cellular Measurements of Non-Specific Endocytosis to Assess the Target-Independent Clearance of Monoclonal Antibodies
Mark A. Bryniarski, Md Tariqul Haque Tuhin, Carolyn D. Shomin…·Kip P. Conner
The paper develops a cell-based assay to measure non-specific endocytosis of monoclonal antibodies and shows that high non-specific uptake correlates with target-independent clearance and low bioavailability.
8 citations