Astrocyte-secreted glypican-4 drives APOE4-dependent tau pathology
Sivaprakasam R. Saroja, Kirill Gorbachev, Julia TCW, Alison Goate, Ana C. Pereira
This study identifies glypican-4 as a mediator of APOE4-induced tau pathology through interactions with APOE4 and LRP1 in astrocytes.
bioRxiv · Jul 7, 2021 · PreprintNeuroscience