Julia TCW

Context-dependent regulatory networks connect Alzheimer's disease genetics to microglial inflammatory responses

This study develops cEpiNets to connect Alzheimer's disease genetics to microglial inflammatory responses by integrating epigenomic data across contexts.

MicroRNA-223 Enhances Microglia-Dependent Clearance of Amyloid Beta Plaques and Ameliorates Behavioral Deficits in a Mouse Model of Alzheimer's Disease

This study shows that miR-223 improves cognitive function and reduces amyloid beta plaques in an Alzheimer's mouse model by enhancing microglial clearance.

A TAD-informed aging-brain xQTL atlas of multi-modal and cell-type-resolved regulatory variation

The paper presents an xQTL atlas of regulatory variation in the aging human brain, integrating multiple modalities and cell types across four studies, identifying more variant-molecular-trait associations by including TAD boundaries.

Factorization of Alzheimer's disease genetic risk influences allow patient stratification, predicting disease onset, cognitive decline, and cell-type specific responses

The paper uses matrix factorization to analyze genetic risk variants in Alzheimer's disease, identifying factors that predict disease onset, cognitive decline, and cell-type specific responses.

Loss of age-associated increase in m6A-modified RNA contributes to GABAergic dysregulation in Alzheimer's disease

The paper shows that loss of age-related m6A RNA methylation in Alzheimer's disease brains is linked to GABAergic dysfunction and synaptic issues.

Brain pericytes derived from human pluripotent stem cells retain vascular and phagocytic functions under hypoxia

This study shows that iPSC-derived pericytes retain key functions under hypoxia, suggesting their potential for treating ischemic and neurodegenerative disorders.

Divergent Effects of APOE3 and APOE4 Human Astrocytes on Key Alzheimer's Disease Hallmarks in Chimeric Mice

This study shows that APOE3 and APOE4 human astrocytes differentially affect Alzheimer's disease hallmarks in chimeric mice, with APOE3 reducing and APOE4 worsening pathology.

Brain Cell-based Genetic Subtyping and Drug Repositioning for Alzheimer Disease

This study identifies genetic subtypes of Alzheimer's Disease using cell-based gene networks and polygenic risk scores, then repositions existing drugs for AD treatment.

Non-microglial downregulation of PLCG2 impairs synaptic function and elicits Alzheimer disease-related hallmarks

This study shows that PLCG2 downregulation impairs synaptic function and increases Alzheimer's disease-related markers in neurons.

Molecular signature and functional properties of human pluripotent stem cell-derived brain pericytes

The paper characterizes human iPSC-derived brain pericytes, showing they closely resemble primary pericytes in protein composition and function, and demonstrate therapeutic potential in neurological disorders.

ApoE4 drives maladaptive heterogeneity and immunometabolic responses of astrocytes

This study shows that ApoE4 alters astrocyte immunometabolic responses to inflammation by changing their transcriptional profiles and relying on cRel transcription factor activity.

Human iPSC-derived astrocytes transplanted into the mouse brain display three morphological responses to amyloid-β plaques

The paper transplants human iPSC-derived astrocytes into mouse brains to study their response to amyloid-β plaques, finding morphological changes independent of APOE alleles.

CRISPRi screens in human astrocytes elucidate regulators of distinct inflammatory reactive states

The paper uses CRISPRi screens and single-cell transcriptomics in human astrocytes to identify regulators of inflammatory reactive states and their relevance in disease.

Astrocyte-secreted glypican-4 drives APOE4-dependent tau pathology

This study identifies glypican-4 as a mediator of APOE4-induced tau pathology through interactions with APOE4 and LRP1 in astrocytes.

Integration of Alzheimer’s disease genetics and myeloid genomics reveals novel disease risk mechanisms

This study integrates Alzheimer’s disease GWAS with myeloid epigenomic data to identify risk enhancers and causal genes, implicating myeloid endolysosomal dysfunction in AD pathogenesis.

Cholesterol and matrisome pathways dysregulated in human APOE ε4 glia

This study identifies dysregulation of cholesterol and matrisome pathways in human APOE ε4 glia, linking them to Alzheimer's disease risk.

An Efficient Platform For Astrocyte Differentiation From Human Induced Pluripotent Stem Cells

The paper describes a method to generate highly pure astrocytes from hiPSCs, showing they resemble primary astrocytes and have functional properties relevant to neurological disorders.