Targeting Metabolic Vulnerabilities: Valinomycin Augments the Potency of Bioenergetic Inhibitors in Combatting Drug-Resistant and Dormant Mycobacterium tuberculosis
Arnab Roy, Satish Kushwah, Shashikanta Sau, Puja Kumari Agnivesh, Kishan Kumar Parida, Madhe Divya, Nitin Pal Kalia
This study shows that valinomycin enhances the effectiveness of bioenergetic inhibitors against drug-resistant and dormant Mycobacterium tuberculosis by disrupting the proton motive force.
bioRxiv · Nov 23, 2025 · PreprintMicrobiology