Genetic susceptibility to earlier ovarian ageing increases de novo mutation rate in offspring
Stasa Stankovic, Saleh Shekari, Qin Huang, Eugene J. Gardner, Nick D. L. Owens, Ajuna Azad, Gareth Hawkes, Katherine A. Kentistou, Robin N. Beaumont, Felix R. Day, Yajie Zhao, Kitale Kennedy, Andrew R. Wood, Michael N. Weedon, Ken K. Ong, , Anna Murray
The paper identifies genetic variants linked to ovarian ageing and shows they increase offspring de novo mutation rates, demonstrating heritability of female mutation rate.
medRxiv · Jun 23, 2022 · PreprintGenetic & Genomic Medicine