Nick D. L. Owens

This study shows that glial cell adhesion molecules regulate neural stem cell proliferation by modulating mechanical forces and nuclear integrity in Drosophila.

The paper identifies GATA4's target genes TBX2 and PRDM1 in cardiogenesis using Xenopus and human iPSC models, showing their conserved roles in cardiac development.

This study identifies a 94-bp deletion in the SLC16A1 promoter causing hyperinsulinism by increasing MCT1 expression and triggering inappropriate insulin secretion during physical activity.

The paper identifies chromosome 20p11.2 deletions as a cause of congenital hyperinsulinism by disrupting FOXA2 expression in pancreatic beta-cells.

The paper identifies homozygous loss of function variants in ZNF808 as a cause of pancreatic agenesis in humans, showing its role in repressing transposable elements during pancreatic development.

The paper quantifies DNA methylation changes in human fetal pancreas development, identifying developmental differentially methylated positions and their genomic distribution.

The paper identifies non-coding mutations in a regulatory element of HK1 that lead to inappropriate expression in pancreatic beta-cells and cause congenital hyperinsulinism.

The paper identifies a genetic circuitry where OCT4 activates an antisense lncRNA that represses Suv39h1, linking H3K9 methylation levels to pluripotency in mouse ES cells.

The paper identifies genetic variants linked to ovarian ageing and shows they increase offspring de novo mutation rates, demonstrating heritability of female mutation rate.

This study shows that Esrrb and Nr5a2 are essential for maintaining naive pluripotency in mouse ESCs by regulating the pluripotency network and preventing differentiation.

The paper shows that CTCF and Esrrb maintain nucleosome positioning at gene regulatory regions during DNA replication and mitosis in mouse ES cells.

This study shows maternal factors like Pou5f3 and Sox3 remodel chromatin to define early competence for germ layer formation in Xenopus tropicalis embryos.

The paper investigates zygotic genome activation in frogs, showing that over 1,000 genes activate independently of the N/C ratio and that signaling pathways shape spatial-temporal gene expression patterns.

This study shows how Nanog uses different mechanisms to enhance embryonic stem cell self-renewal by rewiring pluripotency networks and blocking differentiation through histone modification.

The paper investigates how transcription factors maintain gene regulatory information during mitosis by comparing fixation methods and analyzing nucleosome organization.