Ken K. Ong

This study identifies genetic loci associated with childhood eating behaviour and shows they mediate obesity risk through distinct pathways, primarily driven by the child's own genotype.

The paper identifies vmeQTLs for blood DNA methylation variance in MZ twins, showing gene-environment interactions and cell-type effects relevant to immune disease.

This study identifies genetic and proteomic factors influencing pediatric stature across life stages and links them to adult height and type 2 diabetes risk.

A whole genome multiparametric CRISPR screen in progeria identifies new pathways that can reverse cellular aging phenotypes by targeting protein translation and related processes.

The paper identifies rare genetic variants associated with birth weight, highlighting genes involved in adipose tissue regulation, placental function, and insulin-like growth factor signaling.

This study uses population-scale whole genome sequencing to identify novel rare protein-coding variants associated with cardiometabolic traits, revealing new biological mechanisms and gene functions.

This study identifies damaging LXRα mutations linked to reduced triglycerides but increased liver enzyme levels and hepatotoxicity, suggesting LXR's role in liver health and cautioning against its inhibition for MASLD treatment.

This study identifies 31 plasma proteins and expands genetic loci associated with PCOS, highlighting metabolic and hormonal influences and polygenic risk effects on cardio-metabolic outcomes.

The paper identifies genetic impacts on DNA methylation across 724,499 CpGs in blood samples, revealing co-localisations with disease traits and regulatory mechanisms.

The paper identifies chromatin loop rewiring in adipogenesis and discovers novel regulators and gene-trait associations relevant to obesity and diabetes.

The paper identifies protein-truncating variants in BSN associated with severe adult-onset obesity, type 2 diabetes, and fatty liver disease, with no effect on childhood adiposity.

This study identifies fetal and maternal GDF15 as key factors in pregnancy-related nausea and vomiting, showing their roles in disease risk and severity.

The paper identifies genetic variants linked to ovarian ageing and shows they increase offspring de novo mutation rates, demonstrating heritability of female mutation rate.

The paper uses genetic variation to assess the causal impact of food choices on health outcomes, identifying robust associations between eating patterns and several diseases.

The paper identifies genetic variants influencing DNA methylation in blood and shows their associations with complex traits and diseases, but finds limited direct causality.

The paper identifies sex-differential participation bias in genetic studies by performing GWAS on sex in 3.3 million individuals, finding 158 loci associated with sex and highlighting traits like BMI that may influence participation.

This study identifies 370 genetic loci associated with age at first sex and birth, linking them to externalising behaviour and reproductive biology.

This study develops a polygenic and phenotypic risk score for PCOS using EHR data, showing improved detection and identifying shared metabolic and endocrine comorbidities.

The paper identifies genetic determinants of mosaic Y chromosome loss in blood and links it to genomic instability and non-haematological cancer risk.

This study performs a large-scale genome-wide meta-analysis of PCOS cases and identifies genetic loci associated with PCOS and related traits, showing shared genetic architecture across different diagnostic criteria.

This study identifies 78 genetic signals for male puberty timing using a large sample of men, revealing links to hair color and health outcomes.

This study identifies 26 genetic loci associated with reproductive ageing in a Japanese population, highlighting differences in allele frequencies and effect estimates compared to European populations.

The paper investigates the association between maternal serum GDF15 concentrations and nausea/vomiting in pregnancy, finding higher levels in women with vomiting and anti-emetic use.

This study replicates and extends findings of CADM2 and MSRA gene associations with personality traits using data from 23andMe.

This study identifies genetic variants associated with epigenetic age acceleration and shows TERT's role in regulating the DNA methylation clock.

This study identifies genetic loci associated with early childhood growth phenotypes and links them to later adiposity traits, suggesting potential targets for obesity prevention.