Microvascular pathology of proteotoxic endothelial signature characterizes Progressive Supranuclear Palsy
Seojin Lee, Xia Han, Satoshi Tanikawa, Takeru Kuwabara, Koji Yoshida, Shelley L. Forrest, Shojiro Ichimata, Hidetomo Tanaka, Tomoya Kon, Shinya Tanaka, Ekaterina A. Rogaeva, Maria Carmela Tartaglia, Susan Helen Fox, Anthony Edward Lang, Jessica E. Rexach, Gábor Géza Kovács
This study identifies microvascular pathology and endothelial proteotoxicity as key features of Progressive Supranuclear Palsy through neuropathological and single-nucleus RNA-sequencing analysis.
bioRxiv · Jul 21, 2026 · PreprintPathology