This study identifies microvascular pathology and endothelial proteotoxicity as key features of Progressive Supranuclear Palsy through neuropathological and single-nucleus RNA-sequencing analysis.

bioRxiv · Jul 21, 2026 · PreprintPathology

Investigation of the HLA locus in autopsy-confirmed progressive supranuclear palsy

Jinguo Wang, Shelley L. Forrest, Sathish Dasari, Hidetomo Tanaka, Ekaterina A. Rogaeva, Maria Carmela Tartaglia, Susan Helen Fox, Anthony Edward Lang, Subha Kalyaanamoorthy, Gábor Géza Kovács

This study investigates the HLA locus in PSP patients, finding associations between specific HLA alleles and disease risk, suggesting an autoimmune mechanism.

Immunobiology · Mar 22, 2025Peer-reviewedImmunology

4R-Tau seeding activity unravels molecular subtypes in patients with Progressive Supranuclear Palsy

Iván Martínez-Valbuena, Seojin Lee, Enrique Santamaría, Joaquín Fernández‐Irigoyen, Shelley L. Forrest, Jun Li, Hidetomo Tanaka, Blas Couto, Nikolai Gil D. Reyes, Syeda Hania Qamar, Ali Mohammadi Karakani, Ain Kim, Konstantin A. Senkevich, Ekaterina A. Rogaeva, Susan Helen Fox, , Gábor Géza Kovács

The paper investigates molecular subtypes in PSP by analyzing tau seeding activity and identifies immune-related pathways associated with disease progression.

bioRxiv · Sep 28, 2023 · PreprintNeuroscience

Structure-based Classification of Tauopathies

Yang Shi, Wenjuan Zhang, Yang Yang, Alexey G. Murzin, Benjamin Falcon, Abhay Kotecha, M. van Beers, Airi Tarutani, Fuyuki Kametani, Holly J. Garringer, Rubén Vidal, Grace I. Hallinan, Tammaryn Lashley, Yuko Saito, Shigeo Murayama, , Sjors H. W. Scheres

Cryo-EM structures sort four-repeat tauopathies into three-layered (PSP, GGT, LNT) and four-layered (CBD, AGD, ARTAG, MAPT intron 10 mutations) tau folds, grounding a hierarchical structure-based classification.

Nature · Sep 29, 2021Peer-reviewedNeuroscience✦ In-depth digest