Gábor Géza Kovács

This study compares soluble α-synuclein species from MSA and LBD brains, finding differences in their seeding activity and size distribution.

This study identifies microvascular pathology and endothelial proteotoxicity as key features of Progressive Supranuclear Palsy through neuropathological and single-nucleus RNA-sequencing analysis.

The paper identifies a protein-folding stress-associated microglial state in PSP brains and shows it is distinct from DAM, driven by ER stress.

The paper constructs a single-nucleus transcriptome atlas of the orbitofrontal cortex in ALS and identifies cell-type-specific transcriptional changes, introducing a deep learning model to analyze alternative polyadenylation.

The paper identifies a Lewy-MSA hybrid fold of α-synuclein in atypical MSA, linking distinct filament structures to neuronal versus oligodendroglial pathologies.

This study investigates the HLA locus in PSP patients, finding associations between specific HLA alleles and disease risk, suggesting an autoimmune mechanism.

This study identifies genetic variants associated with clinical duration in sporadic CJD but finds no significant SNPs for age at onset.

The paper investigates molecular subtypes in PSP by analyzing tau seeding activity and identifies immune-related pathways associated with disease progression.

This study identifies age-dependent formation of TMEM106B amyloid filaments in human brains using cryo-EM, showing they appear in older individuals but not younger ones.

This study introduces a modified Real-Time Quaking-induced Conversion assay to assess alpha-synuclein seeding activity in multiple system atrophy, revealing heterogeneity in seeding behavior across brain regions.

This study identifies JADE1 as a novel genetic factor in tauopathy through genome-wide association and functional validation in human and Drosophila models.

Cryo-EM structures sort four-repeat tauopathies into three-layered (PSP, GGT, LNT) and four-layered (CBD, AGD, ARTAG, MAPT intron 10 mutations) tau folds, grounding a hierarchical structure-based classification.

The paper identifies the indusium griseum as a prenatal target of psychostimulants and shows that Scgn+/Vglut1+ neurons in this region are critical for neuronal excitability and linked to behavioral abnormalities.

The paper identifies a genetic variant in TECPR2 associated with healthy brain aging and neuroprotection against Alzheimer's disease.