Histone H3.3 Hira chaperone complex contributes to zygote formation in mice and humans.
Rowena Smith, Sue Pickering, Anna Kopakaki, Kok Joo Thong, Richard Allen Anderson, Chih-Jen Lin
This study shows the Hira complex is essential for male pronucleus formation in mice and humans, with Cabin1 and Ubn1 playing critical roles, and demonstrates potential for IVF therapy.
bioRxiv · Jun 18, 2020 · PreprintDevelopmental Biology