Author

Chih-Jen Lin

MRC Centre for Reproductive HealthORCID 0000-0002-1234-4236Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Rowena Smith· 2 shared Andrej ŠušoriD· 1 shared Anna Kopakaki· 1 shared Hao MingiD· 1 shared Janet Tait· 1 shared Kok Joo Thong· 1 shared Marco ContiiD· 1 shared Richard Allen AndersoniD· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersDevelopmental Biology

Rowena Smith

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2 papers

Recent·Most cited

The H3.3 chaperone Hira complex orchestrates oocyte developmental competence

Rowena Smith, Zongliang Jiang, Andrej Šušor, Hao Ming, Janet Tait, Marco Conti, Chih-Jen Lin

This study shows that the Hira complex is essential for oocyte developmental competence by maintaining transcriptional silencing through H3.3 deposition and chromatin modifications.

Development · Feb 3, 2022Peer-reviewedDevelopmental Biology

Histone H3.3 Hira chaperone complex contributes to zygote formation in mice and humans.

Rowena Smith, Sue Pickering, Anna Kopakaki, Kok Joo Thong, Richard Allen Anderson, Chih-Jen Lin

This study shows the Hira complex is essential for male pronucleus formation in mice and humans, with Cabin1 and Ubn1 playing critical roles, and demonstrates potential for IVF therapy.

bioRxiv · Jun 18, 2020 · PreprintDevelopmental Biology