Proximity directs microbial transglutaminase site selectivity in native antibody modification
Riko Nishioka, Koki Murozono, Yoshirou Kawaguchi, Michio Kimura, Shun Sakuraba, Noritaka Hashii, Akinobu Senoo, José M. M. Caaveiro, Mitsuo Umetsu, Noriho Kamiya
This paper demonstrates that fusion-protein architecture determines site selectivity in proximity-directed enzymatic modification of antibodies, enabling site-specific functionalization.
bioRxiv · Aug 20, 2026 · PreprintBioengineering