Somatic evolution in non-neoplastic IBD-affected colon
Sigurgeir Ólafsson, Rebecca E. McIntyre, Tim H. H. Coorens, Timothy M. Butler, Hyunchul Jung, Philip S. Robinson, Henry Lee-Six, Mathijs Arnoud Sanders, Kenneth Arestang, Claire Dawson, Monika Tripathi, Konstantina Strongili, Yvette E. Hooks, Michael R. Stratton, Miles Parkes, , Carl A. Anderson
The paper analyzes somatic mutations in colonic crypts of IBD patients and controls, finding higher mutation rates and clonal expansions in IBD-affected tissue.
Cell · Jul 21, 2020Peer-reviewedGenetics