Hydration Energetics Shape Antibody Discrimination between Sulfotyrosine and Phosphotyrosine
Takahiro Mori, Kotaro Yahagi, Saki Maruoka, Kota Toyoda, Yoshikazu Sonoshita, Yohei Kametani, Yoshihito Shiota, Kazunari Yoshizawa, Keiichi Watanabe, Kyo Okazaki, Yoshihiro Kobashigawa, Hiroshi Morioka, Hideki Hirakawa, Etsuko Nishimoto, Takamasa Teramoto, Yoshimitsu Kakuta
This study shows how PSG2 antibody discriminates between sulfotyrosine and phosphotyrosine through a balance of direct interactions and desolvation effects.
bioRxiv · Aug 11, 2026 · PreprintBiophysics