SARS-CoV-2 infection induces germinal center responses with robust stimulation of CD4 T follicular helper cells in rhesus macaques
Sonny R. Elizaldi, Yashavanth Shaan Lakshmanappa, Jamin W. Roh, Brian A. Schmidt, Timothy D. Carroll, Kourtney D. Weaver, Justin C. Smith, Jesse D. Deere, Joseph Dutra, Mars Stone, Rebecca Lee Sammak, Katherine J. Olstad, J. Rachel Reader, Zhong-Min Ma, Nancy K. Nguyen, , Smita S. Iyer
This study shows SARS-CoV-2 infection in rhesus macaques induces Tfh cells and germinal center responses, with Th1 skewing and early IgG but delayed IgA.
bioRxiv · Jul 7, 2020 · PreprintImmunology