Cell BiologyFrontiers in EndocrinologyPeer-reviewed
Thiamine transporter 2 and Janus kinase 2 inhibitor, fedratinib suppresses thermogenic activation of human neck area-derived adipocytes
Gyath Karadsheh, Kovács Emília, Rahaf Alrifai…·Endre Kristóf
This study shows that fedratinib, a ThTr2 and JAK2 inhibitor, suppresses thermogenic activation in human adipocytes by reducing amino acid consumption and thermogenic gene expression.
DOI 10.3389/fendo.2026.1694542