Iron uptake mediated by TFRC and secretion of transferrin types stimulate thermogenic activation in human adipocytes
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Ágoston Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti
The paper shows that TFRC-mediated iron uptake and transferrin secretion enhance thermogenic activation in human adipocytes by supporting mitochondrial function and oxygen consumption.
FEBS Letters · Feb 28, 2026Peer-reviewedCell Biology