TRAFIKK: systematic prediction and mechanistic interpretation of anticancer drug synergies
Marco Fariñas, Viviam Bermudez, Eirini Tsirvouli, Kristine Lippestad, John Zobolas, Tero A. Aittokallio, Kaisa Lehti, Åsmund Flobak
TRAFIKK predicts and explains anticancer drug synergies by simulating drug effects in cell-specific models, achieving high recall and revealing both conserved and context-dependent mechanisms.
bioRxiv · May 12, 2026 · PreprintSystems Biology