Kaisa Lehti

TRAFIKK predicts and explains anticancer drug synergies by simulating drug effects in cell-specific models, achieving high recall and revealing both conserved and context-dependent mechanisms.

This study shows that mechanical anisotropy in adipose tissues influences ovarian cancer cell migration through TGFβ-dependent mechanisms, independent of MMP activity.

This study integrates chromatin accessibility and transcriptomics data from ovarian tumor-infiltrating adaptive NK cells to identify key transcription factors and their regulatory networks.

This study shows that antigen-specific memory NK cells can be generated in ovarian cancer, enhancing their cytotoxicity and tumor reactivity through NKG2C/A-HLA-E/ABC interactions and CXCR2-mediated migration.

BooLEVARD quantifies paths leading to node activation or repression in Boolean models, enhancing signal strength analysis in signaling networks.

This study shows that IL-21 enhances aNK cell expansion and cytotoxicity against tumors, with tumor lysate boosting their efficacy, validated in a zebrafish model.