A Joint Deep Learning Model for Simultaneous Batch Effect Correction, Denoising and Clustering in Single-Cell Transcriptomics
Justin Lakkis, David Wang, Yuanchao Zhang, Gang Hu, Kui Wang, Huize Pan, Lyle Ungar, Muredach P. Reilly, Xiangjie Li, Mingyao Li
This paper introduces CarDEC, a deep learning model that simultaneously corrects batch effects, denoises, and clusters scRNA-seq data, outperforming existing methods in multiple evaluations.
Genome Research · Oct 1, 2021Peer-reviewedBioinformatics